Google Scholar, ResearchGate Profile
(+ denotes co-first authors, and * denotes corresponding authors)
2025
X. Zeng*, R. V. Pappu*, "Backbone-mediated weakening of pairwise interactions enables percolation in peptide-based mimics of protein condensates", Commun. Chem., 8, 106, 2025.
Y. Bao+, Z. Xu+, K. Cheng*, X. Li, F. Chen, D. Yuan, F. Zhang, A. R.-Y. Che, X. Zeng, Y.-D. Zhao, J. Xia*, "Staudinger Reaction-Responsive Coacervates for Cytosolic Antibody Delivery and TRIM21-Mediated Protein Degradation", J. Am. Chem. Soc., 147, 4, 3830–3839, 2025.
Z. Li, W. Tan, G.-P. Zhao, X. Zeng*, W. Zhao*, "Recent advances in the synthesis and application of biomolecular condensates", J. Biol. Chem., 301 (2), 108188, 2025.
2024
F. Chen, Y. Han, X. Li, W. Guo, C. Wu, J. Xia, X. Zeng*, H. C. Shum*, "Sidechain Chemistry-encoded solid/liquid phase transitions of condensates", bioRxiv, 2024.
H. Chen, Y. Bao, X. Li, F. Chen, R. Sugimura, X. Zeng, J. Xia*, "Cell Surface Engineering by Phase-Separated Coacervates for Antibody Display and Targeted Cancer Cell Therapy", Angew. Chem., e202410566, 2024.
2023
G. M. Wadsworth+, W. J. Zahurancik+, X. Zeng+(co-first author), P. Pullara, L. B. Lai, V. Sidharthan, R. V. Pappu*, V. Gopalan*, P. R. Banerjee*, "RNAs undergo phase transitions with lower critical solution temperatures", Nature Chemistry, 2023, 15, 1693–1704.
X. Zeng and R. V. Pappu*. Developments in describing equilibrium phase transitions of multivalent associative macromolecules, Current Opinion in Structural Biology, 2023, 79: 102540
Y. Dai, M. Farag, D. Lee, X. Zeng, K. Kim, H.-I. Son, X. Guo, M. Ney, D. M. Shapiro, R. V. Pappu, A. Chilkoti*, L. You*, “Programmable synthetic biomolecular condensates for cellular control”, Nat. Chem. Biol., 2023, 1-11.
Publications before 2023
X. Zeng, K. M. Ruff, R. V. Pappu*, "Competing interactions give rise to two-state behavior and switch-like transitions in charge-rich intrinsically disordered proteins", Proc. Natl. Acad. Sci. U.S.A., 119(19)e2200559119 (2022). Recommended in Faculty Opinions.
M. J. Fossat+, X. Zeng+ (+co-first author), R. V. Pappu*, "Uncovering Differences in Hydration Free Energies for Model Compound Mimics of Charged Sidechains of Amino Acids", J. Phys. Chem. B, 2021, 125, 16, 4148–4161.
X. Zeng, C. Liu, M. J. Fossat, P. Ren, A. Chilkoti, R. V. Pappu*, "Design of intrinsically disordered proteins that undergo phase transitions with lower critical solution temperatures", APL Material, 9, 021119 (2021).
X. Zeng, A. S. Holehouse, A. Chiltoki, T. Mittag, R. V. Pappu*, "Connecting Coil-to-Globule Transitions to Full Phase Diagrams for Intrinsically Disordered Proteins", Biophys. J., 2020, 119 (2), 402-418.
X. Zheng*+, X. Zeng+ (+co-first author), Z. Li, "Multiscale simulation and kinetic network model analysis of the self-assembly of amphiphilic systems" (in Chinese), Scientia Sinica Chimica, 2020, 50.
L. Wang, J. Zheng, X. Zeng, P. P.-H. Cheung, X. Zheng, L. Xie, X. Shi, R. Li*, X. Huang*, Y. Wang*, “Mechanistic Insights and Rational Design of a Versatile Surface with Cells/Bacteria Recognition Capability via Orientated Fusion Peptides”, Adv. Sci. 6(9), 1801827 (2019)
X. Zeng, Z.-W. Li*, X. Zheng, L. Zhu, Z.-Y. Sun, Z.-Y. Lu, X. Huang*, “Improving the Productivity of Monodisperse Polyhedral Cages by Rational Design of Kinetic Self-assembly Pathways”, Phys. Chem. Chem. Phys., 2018, 20, 10030-10037.
A. Tyagi, X. Liu, I. H. Abidi, Z. Gao, B. M. Park, X Zeng, X. Ou, A. A. Cagang, M. Zhuang, M. D. Hossain, K. Zhang, L.-T. Weng*, F. Sun*, Z. Luo*, “Modular functionalization of crystalline graphene by recombinant proteins: a nanoplatform for probing biomolecules”, Nanoscale, 10(47):22572-82 (2018)
X. Zeng, L. Zhu, X. Zheng, M. Cecchini*, X. Huang*, "Harnessing Complexity in Molecular Self-Assembly by Computer Simulations", Phys. Chem. Chem. Phys., 2018, 20, 6767-6776, (perspective).
Y. Tian+, X. Zeng+ (+co-first author), J. Li+, Y. Jiang, H. Zhao, D. Wang, X. Huang*, Z. Li*, "Achieving Enhanced Cell Penetration of Short Conformationally Constrained Peptides through Amphiphilicity Tuning", Chem. Sci., 2017, 8, 7576-7581.
L. Meng, F. K. Sheong, X. Zeng, L. Zhu, X. Huang*, “Path lumping: An efficient algorithm to identify metastable path channels for conformational dynamics of multi-body systems”, J. Chem. Phys.,147(4):044112 (2017)
X. Zheng, L. Zhu, X. Zeng, L. Meng, L. Zhang, D. Wang, X. Huang*, “Kinetics-Controlled Amphiphile Self-Assembly Processes”, J. Phys. Chem. Lett.,8(8):1798-803 (2017)
X. Zeng, B. Li, Q. Qiao, L. Zhu, Z.-Y. Lu*, X. Huang*, "Elucidating Dominant Pathways of the Nano-particle Self-Assembly Process", Phys. Chem. Chem. Phys., 2016, 18, 23494-23499 (featured in cover)
J. Zheng, L. Wang, X. Zeng, X. Zheng, Y. Zhang, S. Liu, X. Shi, Y. Wang, X. Huang*, L. Ren*, “Controlling the integration of polyvinylpyrrolidone onto substrate by quartz crystal microbalance with dissipation to achieve excellent protein resistance and detoxification”, ACS Appl. Mater. Interfaces, 8(29):18684-92 (2016)
L. Zhu, F. K. Sheong, X. Zeng, X. Huang*, “Elucidation of the conformational dynamics of multi-body systems by construction of Markov state models”, Phys. Chem. Chem. Phys., 18(44):30228-35 (2016) (featured in cover)
Y. Tian, J. Li, H. Zhao, X Zeng, D. Wang, Q. Liu, X. Niu, X. Huang, N. Xu*, Z. Li*, “Stapling of unprotected helical peptides via photo-induced intramolecular thiol-yne hydrothiolation”, Chem. Sci., 7(5):3325-30 (2016)